Abstract
Although the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.1 Disruption and subsequent dysregulation of gut microbiota-related immunologic processes have also been linked to disease severity and response to treatment.2.
Highlights
Human Proof-of-Concept Intervention Trial lthough the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.[1]
Disruption and subsequent dysregulation of gut microbiota-related immunologic processes have been linked to disease severity and response to treatment.[2]
The so-called gut-lungaxis, referring to the hypothesized interaction between the gut microbiota and the lungs, might be of importance in patients with allergic asthma but mechanistic data from humans are lacking.[4]. This current human intervention trial was designed as a proof-of-concept study, addressing the following question: does modulation of the gut microbiome of adults with allergic asthma influence lung inflammation in a house dust mite (HDM) plus lipopolysaccharide (LPS) provocation model?
Summary
Human Proof-of-Concept Intervention Trial lthough the pathophysiology of asthma is complex, perturbation of the gut microbiota has been associated with an increased risk of asthma development in childhood.[1]. This current human intervention trial was designed as a proof-of-concept study, addressing the following question: does modulation of the gut microbiome of adults with allergic asthma influence lung inflammation in a house dust mite (HDM) plus lipopolysaccharide (LPS) provocation model? After a 36-hour washout period of antibiotics all patients were challenged through HDM/LPS
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