Abstract
Joint pain is common when there is a change in weather. Mostly, cloudy weather is associated with back pain and knee joint pain. Atmospheric pressure plays a shrouded role in inducing and regulating joint pain. Bones are the densest organs of the human body, and that is why it becomes interesting to see the effect of low-density air pressure on such high-density organs. HIF is one factor involved in air pressure sensing, but how it communicates the signal to bones and the gut will be an interesting mechanism to decipher. The surrounding atmosphere also intervenes in the gut microbiome composition and eventually can change the chemistry of gases produced in the hindgut. IL-8, IL-6, and TLR-4 are a few of the signal-carrying molecules for the hindgut. In the manuscript, an attempt has been made to establish a signaling triad between the Gut, Bone, and the environment to formulate a hypothesis.
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