Gut microbe composition and metabolic syndrome

We present a case of a 27-year-old woman in whom idiopathic hypersomnolence was diagnosed in adolescence with adequate symptomatic control on daily dosage of 250 mg of modafinil. She maintained this dosage throughout her pregnancy and during the peripartum period, but did not breastfeed her newborn because of a lack of information on the transmission of modafinil in human breast milk. Samples of her breast milk were obtained at various times over a 24-hour period and analyzed using liquid chromatography mass spectrometry. The relative infant dose was calculated to be 5.3%, below the threshold of concern for drug passage via breast milk. This is the first reported case of modafinil transfer into human breast milk. Given the drug's use in a variety of sleep disorders, the results of this case can be used to advise breastfeeding mothers prescribed modafinil.

Su1041 Non-Alcoholic Fatty Liver Disease (NAFLD) and Metabolic Syndrome Are Associated With Small Intestine Bacterial Overgrowth

International Journal of DermatologyVolume 32, Issue 7 p. 493-498 KERATODERMAS ALEXANDER ZEMTSOV M.D., M.S., Corresponding Author ALEXANDER ZEMTSOV M.D., M.S. From the Departments of Dermatology and Biochemistry, Texas Tech University Health Sciences Center School of Medicine, Lubbock, Texas.Address for correspondence: Alexander Zemtsov, M.D., Department of Dermatology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430.Search for more papers by this authorMARIA VEITSCHEGGER M.D., MARIA VEITSCHEGGER M.D. From the Departments of Dermatology and Biochemistry, Texas Tech University Health Sciences Center School of Medicine, Lubbock, Texas.Search for more papers by this author ALEXANDER ZEMTSOV M.D., M.S., Corresponding Author ALEXANDER ZEMTSOV M.D., M.S. From the Departments of Dermatology and Biochemistry, Texas Tech University Health Sciences Center School of Medicine, Lubbock, Texas.Address for correspondence: Alexander Zemtsov, M.D., Department of Dermatology, Texas Tech University Health Sciences Center, 3601 Fourth Street, Lubbock, TX 79430.Search for more papers by this authorMARIA VEITSCHEGGER M.D., MARIA VEITSCHEGGER M.D. From the Departments of Dermatology and Biochemistry, Texas Tech University Health Sciences Center School of Medicine, Lubbock, Texas.Search for more papers by this author First published: July 1993 https://doi.org/10.1111/j.1365-4362.1993.tb02831.xCitations: 20AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume32, Issue7July 1993Pages 493-498 RelatedInformation

Texas Tech University Health Science Center (TTUHSC) supports a strong undergraduate honors program. Students are required to enter the Honors College as freshmen and enroll in at least 24 hours of honors-designated classes. Some of the clinical core courses in the clinical laboratory science (CLS) program are designated as honors courses so students can continue their contract agreement with the Honors College to enroll in at least six hours of honors credit at the junior and senior level. By providing further educational experiences out of class, these honors students are able to meet the requirements needed to graduate with highest honors. A CLS honors program not only benefits the student but also the faculty involved and the program curriculum.

Gluten-Free Diet: Imprudent Dietary Advice for the General Population?

Is Percutaneous Coronary Intervention Now the Default Revascularization Strategy for Unprotected Left Main Coronary Artery Stenosis?

<P>A 5-year-old Hispanic girl was evaluated for recurrent torticollis over a period of 1 year, which was interfering with regular activities. Cervical spine studies were normal. Ibuprofen, rest, and parental reassurance were given. Two months later, she was evaluated for persistence of torticollis. On exam, she was apprehensive, her head was tilted to the left, and she refused to move her neck. The left posterior-lateral neck region was tender on palpation. The remaining physical and neurological exam was unremarkable. Magnetic resonance imaging (MRI) showed a destructive process of the left portion of the body of C2 extending into the left lamina and dens, not involving the spinal cord or vertebral artery (see Figure 1). An osteomyelitic process with an inflammatory phlegmon was considered. Biopsy revealed a histiocytic infiltrate with S100 and CD1a expression.</P><H4>ABOUT THE AUTHORS</H4><P>Vani Selvan, MD, is Resident Physician PGY-II, Department of Family Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas. Tetyana L Vasylyeva, MD, is Resident Physician PGY-III, Department of Pediatrics, Texas Tech University Health Sciences Center. Curtis Turner, MD, is Associate Professor, Department of Pediatric Hematology and Oncology, Texas Tech University Health Sciences Center. Osvaldo Regueira, MD, is Assistant Professor, Department of Pediatric Hematology and Oncology, Texas Tech University Health Sciences Center. </P> <P>Address correspondence to Osvaldo Regueira, MD, Assistant Professor, Department of Pediatric Hematology and Oncology, Texas Tech University Health Sciences Center, 1400 Coulter Drive, Amarillo, TX 79106; or e-mail <a href="mailto:regueira@att.net">regueira@att.net</a>.</P><P>Dr. Selvan, Dr. Vasylyeva, Dr. Regueira, and Dr. Turner have disclosed no relevant financial relationships.</P><P>The authors would like to thank Kenneth McClain, MD, PhD, Baylor College of Medicine, Texas Children’s Cancer Center/Hematology Service, Houston, Texas, for help with the diagnosis of these patients.</P> <H4>EDUCATIONAL OBJECTIVES</H4><OL><LI>Review the histopathology of Langerhan’s cell histiocytosis (LCH).</LI><LI>Discuss the varying clinical presentations of LCH.</LI><LI>Demonstrate currently recommended management strategies for the different presentations of LCH.</LI></OL>

The purpose of this study is to examine the effects of circuit training on the indexes of sarcopenia and the risk factors of metabolic syndrome in aged obese women. To address the goal, this author selected aged women whose body mass index was higher than 25.0 kg/m2 visiting the welfare center for the aged located in Gangwon-do Province and measured the indexes of sarcopenia and the risk factors of metabolic syndrome after circuit training. Through that, this study has gained following results. First, after circuit training, aged obese women’s indexes of sarcopenia indicated statistically significant difference in terms of interaction between the measuring times and groups. Second, after circuit training, aged obese women’s risk factors of metabolic syndrome (systolic blood pressure, diastolic blood pressure, fasting blood sugar, triglycerides, high-density lipoprotein-cholesterol, and waist circumference) showed statistically significant difference in terms of interaction between the measuring times and groups. To sum up the above results, circuit training improves aged obese women’s indexes of sarcopenia and risk factors of metabolic syndrome positively, which means circuit training is found to be effective. Therefore, the circuit training intervention enhances aged obese women’s muscular and metabolic functions positively. As it helps prevent and manage the risk factors of sarcopenia and metabolic syndrome resulted from aging, it will elevate life quality in senescence.

BackgroundThe widespread dissemination of unhealthy dietary habits, childhood-teenage obesity, and sedentary lifestyle in young adults has paved the way for public health burden metabolic syndrome and early onset of type 2 diabetes mellitus. The aim of this study was to assess the prevalence and risk factors for metabolic syndrome and diabetes among young adult students.MethodsThis cross-sectional study was conducted among students of age group (18 to 25 years) studying at Manmohan Memorial Institute of Health Sciences and Central Institute of Science and Technology. The diabetes risk score of each individual was calculated by the Finnish Diabetes Risk Score (FINDRISC tool). Independent risk factors for diabetes and metabolic syndrome were measured by multivariable logistic regression analysis. The p-value of <0.05 was considered statistically significant in this study.ResultsA total of 825 students were recruited and 739 (89.6%) students completed the study with all the fulfilled criteria. The metabolic syndrome (Harmonized Joint Scientific Statement (HJSS) criteria) was present in 7.1%, and the most prevalent defining component was low HDL-C (78%); 74.8% of students were under low risk, 22.18% were at slightly elevated risk, 2.02% were at moderate risk, and 1.01% were at high risk of diabetes. The cardiometabolic risk factors like BMI, TC, and LDL-C were higher at a significant level (p<0.001) with an increased diabetes risk score. Independent lifestyle risk factor for metabolic syndrome was current smoking (AOR, 4.49, 95% CI 1.38–14.62) whereas, an independent lifestyle risk factor for diabetes was low adherence to physical exercise (AOR, 4.81, 95% CI, 2.90–7.99).ConclusionMetabolic syndrome is present, although in low numbers in young adults putting them at risk to develop diabetes in the near future. Early assessment of metabolic syndrome and diabetes risk in young may provide insights for preventive and control plans for risk population.

International Journal of DermatologyVolume 27, Issue 2 p. 98-100 Pseudoxanthoma Elasticum Kenneth H. Neldner M.D., Corresponding Author Kenneth H. Neldner M.D. From the Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TexasAddress for correspondence: Kenneth H. Neldner, M.D., Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX 79430.Search for more papers by this author Kenneth H. Neldner M.D., Corresponding Author Kenneth H. Neldner M.D. From the Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TexasAddress for correspondence: Kenneth H. Neldner, M.D., Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock, TX 79430.Search for more papers by this author First published: March 1988 https://doi.org/10.1111/j.1365-4362.1988.tb01280.xCitations: 56AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume27, Issue2March 1988Pages 98-100 RelatedInformation

Annals of NeurologyVolume 19, Issue 6 p. 613-613 Notes and Letter Reply G. C. Román MD, FACP, G. C. Román MD, FACP The Ministry of Health and Colombian National Institute of Health, Bogotá, Colombia Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TXSearch for more papers by this authorL. N. Román MD, L. N. Román MD The Ministry of Health and Colombian National Institute of Health, Bogotá, Colombia Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TXSearch for more papers by this authorB. S. Schoenberg MD, DrPH, B. S. Schoenberg MD, DrPH Neuroepidemiology Branch, Intramural Research Program, NINCDS, Bethesda, MDSearch for more papers by this authorP. S. Spencer PhD, P. S. Spencer PhD Institute of Neurotoxicology, Albert Einstein College of Medicine, Bronx, NYSearch for more papers by this author G. C. Román MD, FACP, G. C. Román MD, FACP The Ministry of Health and Colombian National Institute of Health, Bogotá, Colombia Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TXSearch for more papers by this authorL. N. Román MD, L. N. Román MD The Ministry of Health and Colombian National Institute of Health, Bogotá, Colombia Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TXSearch for more papers by this authorB. S. Schoenberg MD, DrPH, B. S. Schoenberg MD, DrPH Neuroepidemiology Branch, Intramural Research Program, NINCDS, Bethesda, MDSearch for more papers by this authorP. S. Spencer PhD, P. S. Spencer PhD Institute of Neurotoxicology, Albert Einstein College of Medicine, Bronx, NYSearch for more papers by this author First published: June 1986 https://doi.org/10.1002/ana.410190627Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume19, Issue6June 1986Pages 613-613 RelatedInformation

The purpose of this descriptive study was to identify the time requirements to implement the lead position (course facilitator) for nursing courses at a health sciences center school of nursing located in the southwestern United States. Faculty participants completed instruments dividing tasks into pre-course, within-course, and post-course responsibilities. The results of this study revealed that more than 1 hour per week was spent in pre-course and post-course activities and 3.79 hours per week were spent in within-course activities. Recommendations include examining tasks requiring large amounts of time for management alternatives; developing workload expectations that accurately reflect pre-course, within-course and post-course time requirements; and using course facilitators as mentors when preparing novice faculty for the course facilitator role. Although the results of this study are not generalizable, the findings represent formal assessment of a critical component of the faculty role and suggest the need for further investigation into the demands placed on nursing faculty.

Molecular techniques are playing an ever-increasing role in all areas of anatomic and clinical pathology. The field is currently in need of well-trained technologists in this area of the clinical laboratory who are situated to bridge the current state of practice and the continuing developments in high complexity testing. For the close term, use of "home-brew" and analyte specific reagents (ASR)-based tests will require well-trained personnel with strong biomedical science backgrounds and a thorough understanding of technologies used in assay development. Here, we discuss the selection and evaluation of molecular diagnostic training preceptor sites and tasks indicated for trainees that most meet the needs of the newest facet of the laboratory. We present evaluation tools developed over the course of four years of clinical education used to assess practical performance of trainees in a molecular diagnostic pathology laboratory and conclude with considerations for future training of laboratory technologists.

Association of Increased Cardiorespiratory Fitness with Low Risk for Clustering of Metabolic Syndrome Components in Asymptomatic Men

Targeting the Gut Microbiota in Coronavirus Disease 2019: Hype or Hope?