Abstract
PCOS is defined as a kind of endocrine and metabolic disorder which affects females at reproductive ages, is becoming much more common, nowadays. Microbiomes are known as microorganisms that inhabit the body to play a vital role in human health. In recent years, several basic and clinical studies have tried to investigate the correlation between the reproductive health/disorder and microbiomes (gut microbiomes and vaginal microbiomes). However, the mechanism is still unclear. In this review, we reviewed the relationship between PCOS and microbiomes, including gut/vaginal microbiomes compositions in PCOS, mechanism of microbiomes and PCOS, and then collectively focused on the recent findings on the influence of microbiomes on the novel insight regarding the therapeutic strategies for PCOS in the future clinical practice.
Highlights
IntroductionPolycystic ovary syndrome (PCOS) [1, 2] is widely defined as a kind of endocrine and metabolic disorder with a combination of signs and symptoms of androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology (PCOM)) [3]
Polycystic ovary syndrome (PCOS) [1, 2] is widely defined as a kind of endocrine and metabolic disorder with a combination of signs and symptoms of androgen excess and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology (PCOM)) [3]
We reviewed the relationship between PCOS and microbiomes, including gut/vaginal microbiomes compositions in PCOS, mechanism of microbiomes and PCOS, and collectively focused on the recent findings on the influence of microbiomes on the novel insight regarding the therapeutic strategies for PCOS in the future clinical practice
Summary
Polycystic ovary syndrome (PCOS) [1, 2] is widely defined as a kind of endocrine and metabolic disorder with a combination of signs and symptoms of androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology (PCOM)) [3]. As the increasing studies aiming at the microbiota, it is widely believed that microbiota has evolved together with the hosts and is becoming an integral part of the human body [7]. The microbiota were called as “second genome” for the human body, indicating that microbiota exerts vital function in human health [9]. Various kinds of microbiota are acknowledged to play roles in influencing physiology balance [10], metabolism process [11], nutrition production [12], and immune mediation [13] under physiological conditions. The complex and delicate balance between the microbiota and the host maintain the health of human. Despite there are various evidences to demonstrate the strong associations between human health and diverse types of microbiota including
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
