Abstract
Glucocorticoids (GCs), corticosterone in rodents and cortisol in humans are endogenous stress hormones that exert key...
Highlights
Glucocorticoids (GCs), corticosterone in rodents and cortisol in humans are endogenous stress hormones that exert key physiological functions [1] on various tissues [2] including liver [3] and skeletal muscle [4]
The treatment of Gum Arabic (GA) significantly (P
The supplementation of GA significantly reduced plasma LDL-c concentrations compared to the control group
Summary
Glucocorticoids (GCs), corticosterone in rodents and cortisol in humans are endogenous stress hormones that exert key physiological functions [1] on various tissues [2] including liver [3] and skeletal muscle [4]. GR acts via different mechanisms [15,16], one of the major mechanisms is transcriptional regulation of its primary target genes through genomic glucocorticoid response elements thereby directly binding to DNA or tethering onto other DNA-binding transcription factors [17]. Catalyzes the production of active corticosterone (CORT) from 11-dehydrocorticosterone in rodents, including in liver [26] and muscles [27] Deregulation regulation of these enzymes has been associated various metabolic disorders including obesity [28], diabetes [29], hypertension [30], and cardiovascular disease [31]. The inhibition of 11β-HSD1 decreases intracellular GCs concentrations [36] and enhances insulin sensitivity both in murine and mice [36]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
