GUİLLAİN-BARRÉ SENDROMUNDA AĞIR ÖZÜRLÜLÜĞÜN ERKEN BELİRTEÇLERİ

Abstract

Objective
 Guillain-Barré syndrome (GBS) is an autoimmune
 neurological disorder with non-negligible morbidity
 and mortality. This study aimed to evaluate different
 patient characteristics and laboratory findings as early
 predictors of severe disability in GBS patients.
 Material and Method
 We retrospectively reviewed the medical records of
 121 patients diagnosed with GBS between January
 1, 2018, and December 31, 2021. Data regarding
 demographic characteristics, presenting complaints,
 co-morbidities, previous infection history, neurological
 examination findings, GBS Disability Scores (GDS)
 on the 1st day and by the end of the first month,
 laboratory parameters of serological and cerebrospinal
 fluid (CSF) examination, electromyoneurography
 results, GBS subtypes, treatments, treatment-related
 complications, and prognoses were recorded.
 Results
 The median age of the 121 patients was 58 (20–87)
 years (n = 73 males, 60%). The average GDS was
 3 on admission and 2 at the end of the first month.
 The serum C-reactive protein (CRP) and CSF protein
 levels were raised, while vitamin D levels were
 reduced. Advanced age, cranial nerve involvement,
 history of infection, admission to the intensive care
 unit (ICU), need for mechanical ventilation (MV),
 presence of complications, high plasma CRP levels,
 neutrophil-lymphocyte ratio (NLR), and plateletlymphocyte
 ratio (PLO) were significantly associated
 with severe disability in GBS patients at day 1 and at
 the end of the first month.
 Conclusion
 We identified multiple characteristics that can predict
 severe disability in GBS patients.