Gulf CARE: Heart failure in the Middle East.

Mohamed Hassan

doi:10.5339/gcsp.2015.34

Abstract

[first paragraph of article] Despite striking improvement in the prognosis and survival in patients with coronary artery disease (CAD), hypertension, and congenital heart disease, the prevalence of heart failure (HF) is still growing. 1–3 HF is the most common cause of hospitalization after normal delivery - approximately 1 million patients are hospitalized annually for HF in the United States. 4 Moreover, the prognosis of HF is relatively poor, with 25% mortality at 1 year and 50% mortality at 5 years (stage D HF: 80% mortality at 5 years) - worse than that of many cancers. 1,2 The clinical profile, and outcome of HF in western population is well demonstrated after the release of several large registries such as Acute Decompensated Heart Failure National Registry (ADHERE) and the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF). 5–7 Based on data from ADHERE registry, lower systolic blood pressure (BP), elevated serum BUN and creatinine, hyponatremia, older age, presence of dyspnea at rest, and absence of chronic beta-blocker were identified as independent predictors of mortality. 5,6

Highlights

Despite striking improvement in the prognosis and survival in patients with coronary artery disease (CAD), hypertension, and congenital heart disease, the prevalence of heart failure (HF) is still growing.[1,2,3] HF is the most common cause of hospitalization after normal delivery - approximately 1 million patients are hospitalized annually for HF in the United States.[4]
Ethnicity may even affect the response to specific therapy, for example, the addition of a fixed-dose combination of hydralazine and isosorbide dinitrate to standard HF therapy offered particular efficacy and significantly lower mortality rate (6.2% vs. 10.2%, p 1⁄4 0.02) in African Americans cohort with HFrEF10 (AHA guidelines Class I recommendations)
Gulf CARE registry was shortly released after the Heart function Assessment Registry Trial in Saudi Arabia (HEARTS) – the first prospective multicentre survey in the Kingdom of Saudi Arabia – that enrolled 2610 acute HF (AHF) patients and has been published in the European Journal of Heart Failure in 2014

Summary

Introduction

Despite striking improvement in the prognosis and survival in patients with coronary artery disease (CAD), hypertension, and congenital heart disease, the prevalence of heart failure (HF) is still growing.[1,2,3] HF is the most common cause of hospitalization after normal delivery - approximately 1 million patients are hospitalized annually for HF in the United States.[4]. Patients with prior stroke had a longer hospital stay (p 1⁄4 0.03) and a significantly higher 1-year mortality rate (32.7% vs 23.2%, p 1⁄4 0.001). The risk of recurrent in-hospital stroke (2.0 vs 11%, p 1⁄4 0.001) and the 1-year mortality rate (30.1% vs 36.8 %, p 1⁄4 0.002) were significantly lower when the primary care provider was a cardiologist rather than an internist.

Results

Conclusion