Abstract
Diastolic heart failure (DHF) is a recently recognized syndrome defined as heart failure with preserved systolic cardiac pump function. We developed a minimally invasive, physiologically relevant, gradual pressure-overload experimental model of DHF in Guinea Pigs (GP). GP were divided into two groups - control and treatment. Based on a dose-response curve and time period study, we established the pressure overload model by surgically implanting Angiotensin II pumps (400ng/kg/min)/saline pumps (0.9%) in female Dunkin Hartley Guinea pigs (400g); up to 12 weeks.
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