Abstract
Immune-mediated neuropathies are a heterogenic group of disorders caused by an autoimmune response and often associated with autoantibodies against various neuronal epitopes. Main pathophysiological mechanisms of nerve injury include immune-mediated demyelination, axonal damage, and vasculitic-induced nerve ischemia.Diagnosis is based primarily on the clinical presentation and course, together with electrophysiological studies, testing for autoantibodies, and when needed, cerebrospinal fluid examination and nerve biopsy. Immune-mediated neuropathies frequently, though not universally, respond to immune therapies including corticosteroids, plasma exchange and intravenous immunoglobulins.KeywordsImmune-mediated neuropathiesautoantibodiesGuillain-Barré syndromeCIDPmultifocal motor neuropathyvasculitic neuropathy
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