Abstract
A 33 year- old gentleman came with a progressive flaccid paraparesis, patchy hyperhidrosis and polyuria following an acute gastro enteritis, ultimately diagnosed as axonal variants-GBS associated with acute pandysautonomia. He was managed successfully with parenteral fluids and desmopressin nasal spray in addition to immunoglobulin.
Highlights
Guillain Barre Syndrome (GBS) is the most common acute inflammatory peripheral neuropathic disorder
The antibodies to GM1, GM1b, GD1a and GalNacGD1a are in particular implicated in acute motor axonal neuropathy (AMAN)
Autonomic instability in GBS is not a common presentation which can vary from labile blood pressure to rare bladder or bowel dysfunction
Summary
Guillain Barre Syndrome (GBS) is the most common acute inflammatory peripheral neuropathic disorder. There are various forms of GBS which manifest as pure motor, pure sensory involvement, autonomic and mixed types. The incidence of pathological subtypes of Acute Motor Axonal Neuropathy (AMAN) and AMSAN neuropathy are virtually alike. Autonomic instability in GBS is not a common presentation which can vary from labile blood pressure to rare bladder or bowel dysfunction.
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