Abstract
BackgroundGuillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system. This neurological disorder has been previously reported in bone marrow transplant recipients but is uncommon after kidney transplantation. Viral infections and calcineurin inhibitors are the main triggers of GBS in renal transplant recipients.Case presentationIn this report, we present a case of a 47-year-old male patient 12 years after his second kidney transplantation who developed GBS due to papillary renal cell carcinoma. Infectious and drug-related origins of GBS were excluded. Despite intensive treatment, graftectomy was performed, after which neurological symptoms resolved.ConclusionsIn kidney transplant recipients, paraneoplastic aetiology should be considered in the differential diagnosis of GBS.
Highlights
Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system
In kidney transplant recipients, paraneoplastic aetiology should be considered in the differential diagnosis of GBS
GBS after transplantation is predominantly linked with infections caused by cytomegalovirus (CMV) [3], Epstein-Barr virus (EBV) [4], Campylobacter jejuni and calcineurin inhibitors [2]
Summary
Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy affecting the peripheral nervous system. Conclusions: In kidney transplant recipients, paraneoplastic aetiology should be considered in the differential diagnosis of GBS. The paraneoplastic aetiology of peripheral polyneuropathy due to renal cell carcinoma [5, 6] or its treatment [7] was previously reported but not in renal transplant recipients.
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