Guillain-Barré Syndrome with Nine Positive Anti-Glycolipid Antibodies - A Case Report

Abstract

Objective: To investigate the clinical characteristics of nine glycolipid antibody-positive patients. Method: The clinical data of a patient with Guillain-Barré syndrome were retrospectively analyzed. Result: A 69-year-old woman presented with dysphasia, cough when drinking water, and weakness of the extremities after diarrhea.Physical Examination: Dysarthria, shallowness of the right nasolabial groove, weakness of uplift over the soft palate on the right side, and weakness of the right pharyngeal reflex. Muscle strength was grade 2 proximal, grade 3 distal, and grade 4 inferior. The muscle tone of the extremities was reduced, and bilateral biceps, biceps, radial, knee tendon, and Achilles reflexes were not elicited. Electromyogram: Multiple peripheral nerve lesions: motor nerve involvement; axonal, demyelinating lesions coexist. Serum autoimmune peripheral nerve antibody profiles suggested anti-Sulfatide IgG(+), anti-GD1a IgG(+), IgM(+), anti-GT1a IgG(+), IgM(+), anti-GT1b IgG(+), IgM(+), anti-GQ1b IgG(+), IgM(+).Weakness of the extremities recovered after gamma globulin treatment. Result: The purpose of this study was to gain a better understanding of the clinical features of Guillain-Barré syndrome in a small number of patients who were positive for nine anti-glycemic antibodies and did not exhibit typical symptoms corresponding to a single glycemic antibody.