Abstract

Guideline on the use of iodinated contrast media in patients with kidney disease 2018

Highlights

  • Diagnostic imaging using iodinated contrast media is an essential procedure in the clinical setting and provides a large amount of beneficial information

  • Answer: 1. It is highly likely that the risk of developing contrast‐induced nephropathy (CIN) after coronary angiography (CAG) increases in chronic kidney disease (CKD) patients, as the risk increases as kidney function decreases

  • In a study investigating the association between CIN and cardiovascular events in 9512 patients who underwent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS), CIN occurred in 12.7% of patients and the incidence of cardiovascular events was significantly higher in CIN-onset patients than in the patients who did not develop CIN 1 year after PCI (22.0 vs. 15.4%, p < 0.0001)

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Summary

Purpose of the revision of the guideline

Diagnostic imaging using iodinated contrast media is an essential procedure in the clinical setting and provides a large amount of beneficial information. This book, which was published in Tokyo Igakusya, was approved by JSN, JRS and JCS Science Advisory and Coordinating Committee in 2018 This is the English version of that Japanese book. The Japan Radiological Society (JRS), the Japanese Circulation Society (JCS), and the Japanese Society of Nephrology (JSN) collaborated and published a guideline on the use of iodinated contrast media in patients with kidney disease (CIN guideline 2012). In our revised CIN guideline, we changed the clinical question (CQ) on the diagnosis of CIN to “How should CIN be diagnosed?” and followed the diagnostic criteria of the previous guideline (“CIN is defined as an increase in serum creatinine (SCr) levels by ≥ 0.5 mg/dL or ≥ 25% from baseline within 72 h after a contrast radiography using iodinated contrast media.”), but decided to include KDIGO’s AKI diagnostic criteria. Since the ESUR guideline 2018 was available after the last meeting of the committee on February 18, 2017, the committee reconfirmed their consistency with the revision of this guideline

A cautionary note on the use of the present guideline
Independent assessment
Future plans
CQ 2‐1 How CIN should be diagnosed?
CQ3‐1 Does the risk of developing CIN increase in CKD patients?
CQ 3‐3 Does diabetes mellitus increase the risk of developing CIN?
CQ3‐5 Does the continuation of diuretics increase the risk of developing CIN?
CQ3‐7 Does the use of NSAIDs increase the risk of developing CIN?
3.10 CQ3‐11 Are risk scores useful as predictors of CIN development?
3.11 CQ3‐12 Does a solitary kidney increase the risk of developing CIN?
Type and volume of contrast media
CQ5‐1 Does the risk of developing CIN after CAG increase in CKD patients?
CQ5‐4 Does the risk of developing CIN after PCI increase in CKD patients?
CQ5‐6 Does the onset of CIN increase cardiovascular events?
Intravenous contrast media administration
CQ7‐1 Does physiological saline hydration decrease the risk of developing CIN?
CQ7‐2 Does oral water intake decrease the risk of developing CIN?
Prevention of CIN: pharmacologic therapy
CQ8‐1 Does the administration of NAC prevent CIN onset?
CQ 8‐2 Does administration of hANP prevent CIN onset?
CQ 8‐3 Does administration of ascorbic acid prevent CIN onset?
CQ 8‐4 Does administration of statins prevent CIN onset?
10.1 CQ10‐1 Dose loop diuretics therapy improve renal recovery after CIN onset ?
10.2 CQ10‐2 Dose hydration therapy improve renal recovery after CIN onset ?
10.3 CQ10‐3 Dose low‐dose dopamine therapy improve renal recovery after CIN onset ?
10.4 CQ10‐4 Does hANP treatment in CIN patients improve recovery from AKI?
Findings
Compliance with ethical standards
Full Text
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