Abstract
Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology. We developed the methodology for fabrication of precisely controllable multiscale hierarchical structures using capillary force lithography in combination with original wrinkling technique for the generation of well-defined native ECM-like platforms by culturing fibroblast cells on the multiscale substrata [1]. This paper provides information on detailed characteristics of polyethylene glycol-diacrylate multiscale substrata. In addition, a possible model for guided extracellular matrix formation from fibroblast cells cultured on bio-inspired configurable multiscale substrata is proposed.
Highlights
Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology
Raw and analyzed data An equipment for sample preparation Cross-sectional and titled images of samples A proposed biology model Scanning electron microscope (SEM) samples were placed on a stub for sputtercoating with platinum
It was hypothesize that controlled shape and orientation of fibroblast cells on multiscale topography could affect the production of ECM molecules from them [1,2,3,4]
Summary
Engineering complex extracellular matrix (ECM) is an important challenge for cell and tissue engineering applications as well as for understanding fundamental cell biology. 1 These authors contributed to this work. Physics, Bioengineering Extracellular matrix, Scaffold, Cell and tissue engineering Raw and analyzed data An equipment for sample preparation Cross-sectional and titled images of samples A proposed biology model Scanning electron microscope (SEM) samples were placed on a stub for sputtercoating with platinum.
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