Abstract
AbstractTwo novel chukrasone‐type limonoids, Guianofruits A and B (1 and 2) were isolated from the fruit oil of Carapa guianensis AUBLET (Meliaceae), a traditional medicine in Brazil and Latin American countries. Their structures were elucidated based on spectroscopic analyses using 1D and 2D NMR techniques, HRFABMS, and X‐ray crystallography. Compounds 1 and 2 were rare chukrasone‐type limonoids that had once been isolated from Chukrasia tabularis. Compounds 1 and 2 were evaluated for their effects on the production of NO in LPS‐activated mouse peritoneal macrophages. The results of the NO inhibitory assay suggested that compound 1 is valuable as a potential inhibitor of macrophage activation.
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