Abstract
Abstract The preparation of pyridine derivatives by condensation of acetoacetic esters and cyanoacetic acids (or its esters and amides) in the presence of ammonia. The formed cyclic dicyano‐imides are called the Guareschi products and this reaction is known as the Guareschi reaction. The study finds that ketones can also condense with cyanoacetic esters or amides in aqueous solution in the presence of piperidine or alkali. This reaction has been applied for the preparation of pyridine derivatives and β‐alkyl glutaric acid.
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