Abstract
A new preparative method of Biguanide salts using guanyl-ο-alkylisoureas (GOA) was proposed. In this study the preparation of some alkylbiguanide salts were examined and suitable reaction conditions were decided. From this result, it was found that GOA salt reacted smoothly with free amine in apueous solution at room temperature and gave biguanide at good yield. Thus, this is applicable for general synthesis of a biguanide salt from an amine, especially a remarkable availavility was noticed in the case of preparation of lower alkylbiguanide salt. As it is known the preparation : lower alkylbiguanide is slightly conducted by means of ordinary method.
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