Abstract
Single-stranded DNA wrapped carbon nanotubes (ssDNA-CNT) have emerged as a promising technology for the sensitive detection of analytes in live cell and in vivo imaging applications. ssDNA wrapping permits the dispersion of individual nanotubes, biocompatibility, cellular uptake, and acts as a molecular mask conferring specific molecular interactions with analytes of interest. However, due to the non-covalent nature of ssDNA-CNT interactions, the polymeric coating can be stripped after introduction to biofluids, causing nanotube aggregation. This results in the fluorescent quenching of nanotube response and limits the ability to probe longitudinal changes in analyte levels. To address this experimental limitation, we evaluate the effect of rose Bengal-mediated guanine functionalization on long-term colloidal stability and functionality of ssDNA-CNT-based sensors in biofluids.
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