Abstract
FIFTY years have passed since the introduction of insulin into medicine. It is not widely known that guanidine derivatives were first used in the therapy of diabetes at about the same time, and that the effects of guanidine in a biologic system were first described nearly 100 years ago.1 Over the years, a wide variety of guanidine derivatives have become important investigational tools, as well as major therapeutic agents. Table 1 shows some of these compounds and the extensive range of their activities and uses. It is tempting to conclude that the common structural feature, the guanidine residue, confers no more specificity . . .
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