Abstract
Guanethidine injection blocks the water imbibition response to estrogen in the uteri of adrenalectomized immature rats. In the same experiments guanethidine injection, with or without estrogen, was followed by a 2- to 9- fold elevation in the in vivo uptake of 3H-cytidine and MC-leucine into the acid-soluble fractions of the uterus. The estrogen-induced increase of 14C-leucine incorporation into protein under in vivo conditions was blocked by guanethidine. However, this effect of guanethidine was no longer observed when the uteri were transferred to an in vitro incubation containing the labeled amino acid. Estrogen effects on in vivo 3H-cytidine incorporation into RNA and on in vitro U-14C-glucose metabolism to CO2 were also unaffected by guanethidine. It is suggested that guanethidine interferes with only limited aspects of the uterine response to estrogen. (Endocrinology 86: 909, 1970)
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