Abstract
Effects of anesthetics, sympathomirnetic amines, reserpine, phenethylhydrazine, and cocaine on hypotensive action of guanethidine and [2-(hexahydro-1-azepinyl)ethyl]guanidine sulfate were examined in rats.Guanethidine possessed a lasting hypotensive action in urethane anesthetized rats, whereas only temporary depression was observed in rats anesthetized with pentobarbital sodium, thiopental sodium, secobarbital sodium, or chloralose. The hypotensive action of guanethidine decreased after previous administration of reserpine and cocaine. Furthermore, guanethidine and [2-(hexahydro-1-azepinyl)ethyl]guanidine sulfate showed hypertensive action after pretreatment with phenethylhydrazine in rats anesthetized with urethane.The pressor action of adrenaline and noradrenaline were potentiated, but effect of tyramine was inhibited by guanethidine and [2-(hexahydro-1-azepinyl)ethyl]guanidine sulfate. These were also observed after section of the spinal cord at C1-C2.It was concluded that hypotensive action of [2-(hexahydro-1-azepinyl)ethyl]guanidine sulfate and guanethidine was mainly due to the depletion of endogeneous catecholamines from peripheral stores.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
