Abstract
Serum guanase activity was studied in 71 patients with renal diseases and in 30 normal individuals. A significant increase of serum guanase activity was recorded in 73.3 per cent of patients with endemic nephropathy. Only in isolated cases of chronic glomerulonephritis and chronic pyelonephritis, guanase activity was shown to be slightly increased. It is admitted that increased guanase activity in patients with endemic nephropathy is due to destructive lesions and cytolysis in the epithelial cells of the renal tubuli and, possibly, in the liver parenchyma as well. No correlation was found between increased serum guanase activity, on the one hand, and the degree of nitrogen retention, glomerular filtration and flocculation tests, on the other.
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