Gualou-Xiebai-Banxia decoction combined with convetional therapy for the patients with coronary heart disease angina pectoris (stagnancy of qi and blood stasis) and heart failure

Abstract

Objective To evaluatethe effect of Gualou-Xiebai-Banxia decoction combined with convetional therapy for the patients with coronary heart disease angina pectoris (stagnancy of qi and blood stasis). Methods A total of 62 patients with angina pectoris (stagnancy of qi and blood stasis), randomly divided into 2 groups according to the random number table. The control group was treated with isosorbide dinitrate tablets, aspirin enteric-coated tablets and atenolol hydrochloride tablets; the observation group was treated with Gualou-Xiebai-Banxia decoction on the basis of the control group. Both groups were treated for 30 days. The changes of symptoms, signs and electrocardiogram were observed. The B-type brain natriuretic peptide (BNP) and surum CRP was measured by immunoradiometric method. The clinical curative effect was evaluated. Results The total effective rate was 96.8% (30/31) in the observation group and 83.9% (26/31) in the control group. There was significant difference between the two groups (χ2=6.287, P=0.023). The total effective rate of TCM patterns was 87.1% (27/31) in the observation group and 71.0% (22/31) in the control group. There was significant difference between the two groups. The total effective rate of ECG was 96.8% (30/31) in the observation group and 83.9% (26/31) in the control group. There was significant difference between the two groups (χ2=6.287, P=0.023). After treatment, the serum levels of CRP (4.22 ± 1.87 mg/L vs. 7.21 ± 1.88 mg/L, t=5.643), BNP (31.87 ± 12.58 mg/L vs. 59.28 ± 13.21 mg/L, t=6.769) and plasma viscosity (1.32 ± 0.02 mPa•s vs. 1.57 ± 0.04 mPa•s, t=5.769) in the observation group were significantly lower than those in the control group (P<0.01). Conclusions The Gualou-Xiebai-Banxia decoction combined convetional therapy could improve the clinical symptoms of the patients with coronary heart disease angina pectoris (stagnancy of qi and blood stasis) , could also reduce the serum CRP, BNP levels and blood viscosity. Key words: Angina Pectoris; Qi stagnation and blood stasis of heart; Gualou-Xiebai-Banxia decoction; Integrated Chinese traditional and western medicine therapy