Abstract
GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic DiseasesThe aim of the current preliminary case-control study was to identify glutathione S-transferase P1 (GSTP1) Ile105Val allele and genotype frequency and to evaluate its impact on susceptibility to pancreatic diseases in a Serbian population. This study has encompassed 157 patients with three major types of chronic pancreatic pathology: 47 with pancreatic cancer, 50 with chronic pancreatitis and 60 with type 2 diabetes mellitus, as well as 107 healthy individuals. The presence of GSTP1 Ile105Val polymorphism was analyzed using a PCR-RFLP method. Allele 105Val was less frequent in patients with pancreatic cancer (24.5%) and chronic pancreatitis (24.0%) and slightly more frequent in patients with type 2 diabetes mellitus (31.7%) in comparison to healthy individuals (29.9%), but the differences were not statistically significant. Distribution of Ile105Val polymorphism genotypes differed between the analyzed groups, but differences were also not statistically significant. There are only a few studies regarding the role of GSTP1 Ile105Val polymorphism in pancreatic diseases and their results are inconsistent. The significance of GSTP1 Ile105Val polymorphism for pancreatic pathology remains unclear and further studies are needed in order to elucidate its role in pancreatic diseases.
Highlights
Three major types of chronic pancreatic pathology, pancreatic cancer, chronic pancreatitis and type 2 diabetes mellitus, have been under intensive investigation for many years, but their etiology, genetics and underlying molecular mechanisms still remain unclear [1, 2]
122 Nikoli} et al.: glutathione S-transferase P1 (GSTP1) Ile105Val polymorphism in pancreatic diseases ronmental factors that might be associated with these diseases, special attention has lately been given to xenobiotic metabolizing enzymes, which play a crucial role in cell protection from reactive chemical intermediates and oxidative stress
Analysis of GSTP1 Ile105Val polymorphism was performed in 157 cases of pancreatic pathology and 107 healthy individuals by the PCR-RFLP method
Summary
Three major types of chronic pancreatic pathology, pancreatic cancer, chronic pancreatitis and type 2 diabetes mellitus, have been under intensive investigation for many years, but their etiology, genetics and underlying molecular mechanisms still remain unclear [1, 2]. 122 Nikoli} et al.: GSTP1 Ile105Val polymorphism in pancreatic diseases ronmental factors that might be associated with these diseases, special attention has lately been given to xenobiotic metabolizing enzymes, which play a crucial role in cell protection from reactive chemical intermediates and oxidative stress. Glutathione-S-transferases (GSTs) are a superfamily of phase II xenobiotic-metabolizing enzymes that catalyze the conjugation of reduced glutathione (GSH) to a wide variety of exogenic and endogenic electrophilic molecules. This process generally results in biologically less active compounds that are more water soluble, thereby facilitating their biliary or urinary excretion [6]. Numerous polymorphisms occur in the genes encoding GSTs, which are associated with a lack or an alteration of enzymatic activity toward several substrates [6, 7]
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