Abstract
Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play important roles in neutralization of toxic compounds, and protecting hosts against cancer. Among several GSTs, Glutathione S-transferases mu (GSTM) has been drawn attention upon the association with the genetic risk for many types of cancers. But whether the GSTM1 polymorphisms confer the susceptibility to colorectal cancer in Asians has not been well established. We searched the PubMed database with GSTM1, polymorphism and colorectal cancer, attempting to identify the eligible studies. In total, 33 case-control studies in Asian populations with 8502 colorectal cancer patients and 13699 controls were included in the current meta-analysis. The association between the polymorphism and susceptibility to colorectal cancer was evaluated by the odds ratio (OR) and 95% confidence intervals (CI). The pooled meta-analysis suggested that GSTM1 null variant was correlated to the colorectal cancer risk in Asians. There was a marginal heterogeneity among these eligible studies. Nevertheless, cumulative meta-analysis observed a trend of an obvious association between the GSTM1 null genotype and colorectal cancer risk in Asians. In summary, the meta-analysis suggested that GSTM1 null polymorphism confer the susceptibility to colorectal cancer in Asians, especially in Chinese populations.
Highlights
Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play important roles in neutralization of toxic compounds, and protecting hosts against cancer
Previous evidence suggested that the environmental risk factors and genetic factors both affected the pathogenesis of colorectal cancer[7]
Titles and abstracts of these searching studies were primarily screened and full papers were further retrieved to confirm eligibility, the reference lists were examined to find other relevant studies. These studies were reported from 1996 to 2014. These given studies included into our meta-analysis had to meet the following inclusion criteria: (1) case-control validation study, (2) the studies should estimate the association of the Glutathione S-transferase M1 (GSTM1) null variant with risk to colorectal cancer, (3) the studies should provide odds ratio (OR) with 95% confidence intervals (CI) or available data, (4) the studies should be conducted in Asian populations
Summary
Glutathione S-transferases (GSTs) are enzymes which expressed in many tissues and play important roles in neutralization of toxic compounds, and protecting hosts against cancer. Whether the GSTM1 polymorphisms confer the susceptibility to colorectal cancer in Asians has not been well established. We searched the PubMed database with GSTM1, polymorphism and colorectal cancer, attempting to identify the eligible studies. 33 case-control studies in Asian populations with 8502 colorectal cancer patients and 13699 controls were included in the current meta-analysis. The pooled meta-analysis suggested that GSTM1 null variant was correlated to the colorectal cancer risk in Asians. Cumulative meta-analysis observed a trend of an obvious association between the GSTM1 null genotype and colorectal cancer risk in Asians. The meta-analysis suggested that GSTM1 null polymorphism confer the susceptibility to colorectal cancer in Asians, especially in Chinese populations. Glutathione S-transferase M1 (GSTM1) encodes the mu class of GSTs, which plays vital roles in protecting hosts against cancers[13]. The mu GST enzymes were demonstrated to be more effective at the process of detoxifying cytotoxic and genotoxic reactive species than other
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