Abstract
KEYWORDS Micronuclei; oral carcinoma; leukoplakia; CYP; GSST; polymorphism ABSTRACT Individual cancer susceptibility is the result of several host factors, including differences in life-style habits and genetic susceptibility. There is a correlation between CYP1A1 polymorphism ( Msp I) and oral cancer susceptibility. Individuals carrying the deletions of GSTM1 and GSTT1 are at high risk of developing oral cancers. Again an increased risk of oral carcinoma is indicated by an increased micronuclei frequency. In the present study on tribal and non-tribal population of Assam, CYPm2m2 genotypes were found in about 14.05% cases having leukoplakia and other oral problems. In the same cases GSST null genotypes were found to be 24.35%. In comparison to the controls the micronuclei frequencies were found to be one fold increased for the cases. In spite of having heavy exposure to the carcinogens due to tobacco chewing and bidi smoking, regular tea drinking is decreasing the risk of developing cancer to very little extent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
