Abstract

Purpose: The purpose of this study is to identify factors associated with severe late toxicity and prognosis in women with locally advanced cervical cancer treated with definitive chemoradiation (CRT) and high dose rate (HDR) radiation therapy boost. An increased rate of GI toxicity when Bevacizumab is administered in combination with high doses of abdominal radiation therapy such as stereotactic body radiotherapy (SBRT) has been demonstrated in other malignancies. Our aim is to compare the risk of Grade 3+ toxicity in patients who receive Bevacizumab after HDR brachytherapy in comparison with other risk factors.

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