Abstract
A laboratory system has been developed in which the atmosphere and fluid dynamics of the upper tracheobronchial (TB) tree of the human are simulated. It is used to measure the hygroscopic growth rates of monodisperse NaCl and bronchodilator (Isuprel ® hydrochloride with and without glycerine) aerosols. Dry particles are mixed with water vapour-laden air at the entrance to a growth chamber temperature controlled at 37°C with a relative humidity (RH) between 88 and 95%. Hygroscopic growth rates increased with degree of RH and magnitude of Reynolds number in the chamber. The growth data are incorporated into an aerosol deposition model to calculate the effect of hygroscopic growth upon the dose distribution of medicinal aerosols in the human TB network. The model uses some original deposition formulae to compute particle deposition efficiencies. Calculations show that the rate of water vapour absorption within TB airways is an important factor affecting the fate of particles used in aerosol therapy.
Highlights
THE SUCCESS of aerosol therapy in the treatment of obstructive lung diseases may be related to the total dose delivered to the lung and its regional distribution (MORROW, 1974)
The TASK GROUP ON LUNG DYNAMICS (1966) has shown that the efficiency with which inhaled particulate matter is deposited within the human respiratory tract is a function of the mass median aerodynamic diameter (MMAD) of the aerosol particle size distribution
Experimental measurements were made of the hygroscopic rates of growth of dry monodisperse aerosols of sodium chloride and Isuprel® hydrochloride, a therapeutic bronchodilator drug, under conditions simulating the gas dynamics and atmosphere of the human respiratory system
Summary
0003 4878/8./010093-I6S03.0O 0 Pergamon Press Ltd. 1982 British Occupational Hygiene Society. GROWTH RATE MEASUREMENTS AND DEPOSITION MODELLING OF HYGROSCOPIC AEROSOLS IN HUMAN
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