Abstract
STUDIES of mouse and sheep brain in tissue culture have shown that infection with scrapie increases growth potential1–3. Glial cells always seem to predominate in these cultures, and in one case1 there was a more rapid liquefaction of the ambient chicken plasma clot when explants of mouse brain infected with scrapie were used. Furthermore, the scrapie agent continued to multiply in a cell line which had been established from the brain of a mouse with clinical scrapie4. We have tried to quantify the growth potential of brain cells in culture by measuring their capacity to incorporate tritiated thymidine.
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