Abstract
A 12 week feeding trial was conducted to investigate the effect of administration of different dosages of amoxicillin on biophysiological responses: nutritional, haematological, serum biochemical, organosomatic indices and histopathological study of juvenile Clarias gariepinus. One hundred and eighty juvenile C . gariepinus with the mean weight of 10.94 ± 0.01 g were stocked into the different treatments using a completely randomized design. The fishes were fed diets containing iso-nitrogenous crude protein (40%) at 5% body weight, twice a day. Histopathological results showed no visible lesions in some of the tissues of the fish fed with control and amoxicillin diets. However, there were marked pathological conditions that were manifested in some organs like the liver, brain, kidney and intestine of fish. The inclusion of amoxicillin at 0.5% in the diet of C . gariepinus is being advocated in sustainable catfish production in Nigeria.
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