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Abstract
GROWTH OF THE MAMMARY GLAND with hormone treatment has been exten-sively studied in the guinea pig. Crude lipid extracts of placentae, ovaries and corpora lutea were reported to develop ducts or complete lobule'alveolar systems and to cause secretion in some cases in virginal, parous and castrate females and in normal, castrate and immature males (see Turner, i, for review). More recently purified and crystalline estrogens at low dosages have been shown to develop both mammary ducts and complete lobule'alveolar systems equal to that observed at the time of pregnancy (2, 3, 4). The guinea pig thus differs from other laboratory rodents in that complete mammary development can be readily obtained with estrogens in-jected for short periods of time at low dosages.
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