Growth of SJL/J-derived transplantable reticulum cell sarcoma as related to its ability to induce T-cell proliferation in the host: IV. Effect of thymectomy on primary lymphoma incidence

Abstract

The incidence of spontaneous primary lymphoma following adult thymectomy, irradiation, and bone marrow reconstitution was studied in SJL/J mice. A significantly higher incidence of generalized lymphoma was demonstrated in γ-irradiated and bone marrow-reconstituted (XBM) mice as compared to thymectomized, γ-irradiated, and bone marrow-reconstituted (ATx-XBM) mice. Including both localized and generalized lymphomas, ATx-XBM mice showed about half the incidence of XBM mice at 12 months of age. In comparison of XBM vs untreated controls, a much lower incidence of spleen involvement was noted in XBM mice than in untreated controls.