Abstract
SummaryCholesteatoma is a well-known infection resembling a pearl. Its histological aspect is of an epidermal cyst formation characterized by epidermal-keratinized tissue in the middle ear and mastoid that can migrate and erode to adjacent structures.AimTo verify epidermal cyst (cholesteatoma) growth through implantation of auricular skin of a mouse next to its femoral bone.Study designexperimental.Material and MethodTen healthy rats between two and five months of age and of both sexes underwent implantation of auricular skin on the femoral bone during a three-month period. Paraffin-embedded sections were obtained from the sample and stained with hematoxylin and eosin for pathology investigation.ResultsMacroscopic view: round soft yellowish granulation tissue. Microscopic view: keratinizing stratified squamous epithelium cystic formation. The cyst presented innermost corneal layer, resulted from keratinized skin, followed by granulated and squamous layers, and outermost basal layer. Conclusions: Growth of epidermal cyst (cholesteatoma) may start from a transplanted epithelial tissue next to the femoral bone of rats.
Highlights
Cholesteatoma is a well-known infection of the middle ear and was firstly reported by Curveilhier in 1829 as a pearled tumor
Cholesteatoma is a squamous cell cyst, characterized by keratinized epidermoid tissue that can migrate and erode to adjacent structures frequently found in temporal bones and in people with history of chronic middle ear otitis[1,2]
The squamous cell cyst presents an external matrix formed by keratinizing stratified squamous epithelium over a perimatrix of fibroconnective tissue
Summary
Cholesteatoma is a well-known infection of the middle ear and was firstly reported by Curveilhier in 1829 as a pearled tumor. Cholesteatoma is a squamous cell cyst, characterized by keratinized epidermoid tissue that can migrate and erode to adjacent structures frequently found in temporal bones and in people with history of chronic middle ear otitis[1,2]. The squamous cell cyst presents an external matrix formed by keratinizing stratified squamous epithelium over a perimatrix of fibroconnective tissue (connective tissue containing collagenous, elastin and reticulin fibers, lymphocytes, histiocytes and plasmocytes, besides newly formed vessels). The epithelium is similar to the epidermis and its four basic layers can be observed (basal, squamous, granulated and corneal). Cholesteatoma has lytic and migrating characteristics and it may destroy both the ossicular chain and the mastoid bone cavity, leading to intra and extracranial complications
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