Abstract
The Gwich’in, which belong to the Athapaskan language group of Native Americans live in the borderland between Alaska and Canada. We analyzed 29 medicinal plants of this tribe for their growth inhibitory activity against CCRF-CEM T-cell acute lymphoblastic leukemia (T-ALL) cells. The anti-leukemic activity of these plants has not been investigated as yet. Considering the poor cure rates of some ALL forms, there might be a great potential for medicinal plants as resource for natural products to treat T-ALL. We found that the hexane extracts of three plants revealed considerable growth inhibition on CCRF-CEM cells. The 50% inhibition concentrations (IC50) were 6.63 ± 0.03 µg/ml for Cladina mitis, 8.65 ± 0.38 µg/ml for Picea mariana (needles), and 9.67 ± 1.36 µg/ml for Artemisia frigida. Further investigations are required to isolate the active constituents of these plants.
Highlights
The Athapaskans are a large language family of Native Americans living in Alaska and Canada as well as in the southwest and west coast of USA
We focused on the cytotoxic activity of medicinal plants of Gwich’in against leukemia cells, because there is a great need for improvement of therapy options worldwide
The screening of hexane extracts revealed three hits with an inhibition of leukemia cell growth of more than 60% (Fig. 1A)
Summary
We focused on the cytotoxic activity of medicinal plants of Gwich’in against leukemia cells, because there is a great need for improvement of therapy options worldwide. The growth inhibitory activity of medicinal plants was evaluated in vitro towards human CCRF-CEM leukemia cells. Our investigation focused on 29 medicinal plants of the Gwich’in, whose anti-cancer activity had not been investigated yet.
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