Abstract
Growth is impaired in a chronic renal failure. Anemia, acidosis, reduced intake of calories and protein, decreased synthesis of vitamin D and increased parathyroid hormone levels, hyperphosphatemia, renal osteodystrophy and changes in growth hormone-insulin-like growth factor and the gonadotropin-gonadal axis are implicated in this study. Growth is adversely affected by immunosuppressives and corticosteroids after kidney transplantation. Treating metabolic disorders using the recombinant human growth hormone is an effective option for patients with inadequate growth rates.
Highlights
Inadequate growth is a widespread problem in children with chronic renal failure (CRF)
Inadequate growth appears in chronic kidney disease under the influence of various factors, such as poor or insufficient nutrition, metabolic acidosis, anemia, renal osteodystrophy, changes in the gonadotropingonadal axis and insensitivity to growth hormone [1-3]
Routine fundus examination is recommended in order to identify the changes that may occur in the optic disk in children with CRF receiving the growth hormone therapy
Summary
Inadequate growth is a widespread problem in children with chronic renal failure (CRF). Supportive measures and kidney transplantation are used in order to prevent and correct growth disorder in CRF. A great many children with CRF, including those undergone kidney transplantation, continue to experience growth problems despite these measures. Growth Hormone and Chronic Renal Failure Kidney plays an important role in the metabolism of peptide hormones. In CRF, a decrease in the rate of glomerular filtration leads to impairment of the metabolic clearance of the growth hormone and to an increase in half-life. An increase in growth hormone releasing hormone (GHRH) and a decrease in somatostatin levels is seen in CRF. In patients with CRF, a decrease from the normal levels of 40-80% is seen in both GHBP and in growth hormone’s capacity to bind to GHBP. Tissue insensitivity has been recorded with a decrease in the growth hormone in tissue receptors
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