Abstract
Growth hormone (GH) acts in both early and late follicular development to stimulate the proliferation and differentiation of granulosa cells and increase the production of estradiol in animal and human ovaries1-3. Fertility specialists have therefore explored the potential for GH supplementation to improve outcomes in women undergoing in vitro fertilization (IVF), with the greatest interest in women with diminished ovarian reserve, for whom successful fertilization remains a therapeutic challenge4.
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