Growth hormone secretory in healthy aged women and men of Tunisian population

Abstract

With aging, men and women experience multiple hormonal changes, and in particular the activity of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis. This perturbation may be involved in aggravations of numerous abnormalities. In 64 healthy elderly, we determined the concentrations of GH in both sexes and its correlation with thyroid-stimulating hormone (TSH), the descriptive data, BMI, electrolytic assessment and some biochemical parameters. Collected data suggest that there was an age-dependent decrease in GH secretion. For TSH, there was a slight increase. The simple regression analysis revealed non-significant direct relation between these two hormones. We also found that BMI values were inversely related to the serum concentrations of these hormones. For the lipid metabolism, the positively correlated relation only exists between GH and total-cholesterol, on one hand, and between GH and LDL-cholesterol, on the other. For the other parameters such as glucose and triglycerides as well as HDL-cholesterol, this relation does not exist. For the BMI, this index shows a positively correlated relation with glucose and triglycerides. The electrolytic assessment shows that in men, phosphorus was positively related to GH. In women, calcium and sodium were positively related to GH. Aging was found to be associated with decreased morning serum GH levels and slightly increased TSH levels in healthy elderly Tunisian population. Reduction of the GH-IGF-I axis in the elderly has important clinical implications. Indeed, this deficiency in GH could contribute to the decline of various functions associated with normal aging.