Abstract
The receptor for rabbit liver growth hormone (GH) has recently been purified and cloned. Sequencing data demonstrates that this site represents a new class of transmembrane receptor proteins containing covalently linked ubiquitin and N-linked obligosaccharides. Homology with the human GH liver receptor is estimated to be 84%. GH receptors are also present on non-liver cells, however, their function is poorly understood, and it is not yet known if there is homology with the liver site. Direct stimulation of differentiation of preadipocytes to adipocytes by GH has been demonstrated. In bone, binding of GH to the resting cell zone, but not the proliferative layers has been reported. Taken together, these data support the hypothesis of Green and colleagues that GH has a dual mechanism of action which includes direct stimulation of differentiation of precursor cells and a secondary effect of enhancing the clonal proliferative response.
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