Abstract
Growth hormone insensitivity (GHI) is defined as the absence of an appropriate growth and metabolic response to endogenous GH or to GH administered at physiologic replacement dosage (1). Table 1 lists the known conditions associated with GH resistance and their clinical and biochemical features. Only GH receptor (GH-R) deficiency (GHRD) and GH-GHR signal transduction defects are appropriately described as primary GH resistance or insensitivity. Inability to generate insulin-like growth factor-I (IGF-I) resulting from mutation of the IGF-I gene (2) and resistance to IGF-I due to mutation of the IGF-I receptor (3) are properly considered primary IGF-I deficiency and IGF-I resistance.
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