Abstract
(1) The effect of intravenous injection of synthetic TRH (500 μg) on the plasma GH was investigated in six patients in the manic state and five normal volunteers, both before and during lithium treatment, for 3–4 weeks. (2) TRH caused a significant increase in plasma GH in four out of six manic patients during lithium treatment. (3) TRH only raised plasma GH in one patient before lithium treatment. (4) No appreciable change was noted in normal subjects either before or during lithium treatment. (5) The positive GH responses to TRH in manic patients on lithium were observed 90–120 min after TRH except for one patient. (6) The delayed GH response may be caused by secondary effects of TRH on brain monoamine neurotransmitters, rather than by a direct action of TRH on the pituitary.
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