Abstract
Sex steroid hormones can accelerate linear growth in children with growth hormone (GH) deficiency (GHD) without GH therapy. Therefore, GHD may not be suspected in children who are in puberty. LHRH analogue (LHRHa) therapy in children with precocious puberty (PP) has been demonstrated to decelerate the rapid growth velocity associated with elevated sex steroid hormones. We report two children below with PP in whom GHD was diagnosed after their linear growth was decelerated by intranasal administratior of LHRHa (Nafarelin).CA=chronological age in years; BA=bone age in years; GR=growth rate in cm/year: a=before LHRHa therapy, b=during LHRHa therapy, c=combined LHRHa and GH therapyGHD in children with PP may be more common than suspected previously. Recognition of this fact is important since a major complication of PP is short stature as an adult. The combination of GH and LHRHa therapy provided a more normal growth velocity for these children. These findings suggest that for some children with GHD, LHRHa therapy may be indicated to optimize their final adult height. (Supported by FD-R-000097 and USPH RR-00188)
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