Abstract
Growth hormone is an anabolic hormone released in pulsatile manner in the circulation. It is one of the uncommon causes of short stature in children and is largely idiopathic. The case report is about a 12 years old boy who presented with short stature. He was diagnosed to have Growth hormone deficiency. Growth hormone was started after diagnosis was made. Key words: Growth hormone; pituitary. DOI: 10.3126/jnps.v31i2.3260 J Nep Paedtr Soc 2010;31(2):134-136
Highlights
Growth hormone has a well-defined role in promoting childhood growth and in maintaining normal adult body composition
Its production is stimulated by growth hormone-releasing factor and inhibited by somatostatin, which are both produced by the hypothalamus
Growth hormone binds to a specific growth hormone–binding protein (GHBP) and circulates
Summary
Growth hormone has a well-defined role in promoting childhood growth and in maintaining normal adult body composition. Growth Hormone deficiency can be isolated or associated with pituitary disturbances[1]. Epidemiological studies suggest that idiopathic isolated growth hormone deficiency occurs more frequently than multiple pituitary hormone deficiency in children whereas in adult onset GH deficiency is frequently due to pituitary adenomas, surgeries and irradiation[2]. The anthropometric measurements showed; weight-18 kgs and height 110 cms. No abnormalities were present in the chest X-ray His bone age was delayed (Bone age: 7 years). Growth hormone was to be continued till final height was reached. A reasonable approach to stop Growth hormone therapy is to assume that near final height is reached in boys by the age 16. There was a significant increase in his height on follow up after a year and the height velocity was 11 cms following growth hormone therapy.
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