Abstract
Electron micrographs of hepatocytes from hypophysectomized rats when compared with those of normal rats showed increased number or crowding of mitochondria per unit cytoplasmic volume with decreased endoplasmic reticulum, decreased mitochondrial matrix density, and the presence of partitioned mitochondria. After hypophysectomy, the recovery of mitochondrial proteins per gram of wet liver, by centrifugation, was increased. The mean half-life value for the turnover of total mitochondrial proteins was doubled when measured by injection of either l-[4,5- 3H]leucine or l-[guanidino- 14C]arginine. These changes were reversed towards normal by subsequent treatment with growth hormone. These and other results suggest a role for GH in the maintenance of a normal population of properly functioning mitochondria in liver.
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