Abstract
Acromegaly, a clinical syndrome of disordered somatic growth and proportion, is usually caused by the unrestrained secretion of growth hormone (GH) by a pituitary adenoma and rarely may result from GH-releasing hormone (GHRH) secretion by an extrapituitary tumor. The disease was first described more than a century ago and was the earliest pituitary disorder to be recognized. The clinical features of acromegaly are caused by elevated GH and insulin-like growth factor-I (IGF-I) levels.
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