Abstract
THE diabetogenic action of purified preparations of the anterior pituitary growth hormone in normal (1, 2, 3) and in partially depancreatized (4, 5) animals is now well attested. Whether or not this effect is produced by growth hormone uncontaminated by other pituitary hormones is still uncertain, and, in the present unsatisfactory state of knowledge concerning the criteria of purity of proteins, it would be unwise to assume that our best preparations of growth hormone are indeed free from physiologically significant amounts of other substances. The possibility that traces of adrenocorticotropin may be present in our preparations of growth hormone and may play a vital role in the etiology of growth-hormone induced diabetes cannot at present be ruled out. Evidence that the secretion of extra insulin by the pancreatic islets is a condition for the exertion of the normal growth-promoting activity of growth hormone in higher animals is circumstantial and perhaps inconclusive, although we nevertheless believe ...
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