Abstract
The association of hypopituitarism and growth hormone (GH) deficiency with increased cardiovascular mortality has become increasingly well established. In GH-deficient adults, whether the onset of disease is in childhood or in adult life, a higher prevalence of atherosclerotic plaques and endothelial dysfunction has been described. Of note, high-resolution ultrasonography has shown that patients with hypopituitarism have a higher prevalence of premature atherosclerosis even in the absence of clinical symptoms. Specific anatomic abnormalities also have been described in adults with GH deficiency, including an increase in intimal-medial wall thickness. The contribution of specific hormonal factors and prior irradiation to the development of vascular disease remains controversial.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
