Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women.

Chang-Ming Gao,Jin-Hai Tang,Kazuo Tajima,Yan-Ting Liu,Jian-Hua Ding,Hai-Xia Cao,Jian-Shong Wu,Su-Ping Li

doi:10.7314/apjcp.2015.16.13.5421

Chang-Ming Gao, Jin-Hai Tang + Show 6 more

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https://doi.org/10.7314/apjcp.2015.16.13.5421

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Abstract

To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases (χ2=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI<25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.

Highlights

The growth hormone (GH) gene is associated with altered GH production
Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with growth hormone 1 (GH1) A allele were at a decreased risk of breast cancer only among inactive individuals
Stratified analysis by body mass index (BMI) showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI

Summary

Introduction

The growth hormone (GH) gene is associated with altered GH production. Human growth hormone-1 (GH1) is a multifunctional hormone, the adequate circulating levels of GH1 is necessary for normal accretion of skeletal and soft tissues (Florini et al, 1996), and GH1 is believed to be responsible for mammary development (Laban et al, 2003). Epidemiology study indicates that the circulating levels of IGF-I are associated with increased risk of several common cancers (Wolk et al, 1998), including breast cancer (Allen et al, 2005; Fletcher et al, 2005; Al-Zahrani et al, 2006; Lukanova et al, 2006; Schernhammer et al, 2006), but these results are controversial (Kaaks et al, 2002; Schernhammer et al, 2005). We have found that the GH1 T1663A A/A genotype can decrease the risk for colorectal cancer (Gao et al, 2010). Chang-Ming Gao et al Khoury-Shakour et al (2008) found that recreational physical activity modifies the association between GH1 polymorphism and colorectal cancer risk. We assessed influence of the recreational physical activity and body mass index (BMI) to the association between GH1 T1663A Polymorphism and breast cancer risk

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