Abstract
It has been shown previously [6] that the growth of tumours with a constant doubling time may be described by an equation linking the growth fraction and cellular losses. It is shown in this paper that analysis of chemotherapeutic response of measurable tumours may lead to the quantitative evaluation of the growth fraction and of the resistant population to the drug employed. The mathematical model describing the response also allows decisions to be made about the connection between schedule and doubling time, and about the superiority of a simultaneous combination over a sequential one. The parameters employed in such a model may be measured and used by the therapist in clinical cases in order to optimize the treatment.
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