Abstract

Growth factors are part of the cascade triggering neovascularization.1,2 Such neovascularization occurs in the cornea (CNV), although usually not very aggressively, as a possible side effect of contact lens (CL) wear.3 Among the factors involved in this CNV process are fibroblast growth factors such as basic fibroblast growth factor (bFGF). The presence of various vasculogenic growth factors, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α), has been reported in active form in the tear fluid of CL wearers.4,5 The present study investigated the effect of the presence of CL on the concentration of fibroblast growth factors in the surrounding medium by determining the concentration of bFGF in the presence of unworn and worn CLs.

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