Abstract
Epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha) were estimated in extracts of 193 malignant ovarian samples, 42 benign ovarian samples and 71 normal ovaries. TGFalpha was present in 87% of malignant ovaries, 85.7% of benign ovarian tumours and 85.9% of normal ovaries. EGF was present in 30% of malignant ovaries, 35.7% of benign ovarian tumours and 12.7% of normal ovaries. TGFalpha was significantly elevated in both the malignant ovarian and benign ovarian extracts compared to normal ovaries. The median values for EGF was significantly elevated in the benign ovarian group compared to extracts from both malignant and normal ovaries.
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